hrm...you should be able to think that one through..
MDF:
+ easy to work with
easy to cut
cheap (if you get "packing sheets")
easy to make corners with
easy to sand
flat surface for trimming
non toxic
good for you
the dust tastes sort of like a poor man's half empty chip packet, so get into it.

has no other ill effects on the respiratory system, so no need for any sort of protection.

easier to snort with a $5 note than metal shavings or wet fibreglass resin
-
hard to make curves
heavy
Fibreglass: +
like clag and paper mache for grown ups
smells funky
can make complex curves
lightweight (high strength to weight)
easy to do again if you bugger it up
-
expensive
needs a lot of sanding to get it flat for trimming
smells funky
toxic
bad for you
goes everywhere
Sheet metal: +
looks SICK!
-
expensive
hard to work with
heavy
so ideally, you'd make:
the rear of the sub box in fibreglass, so it corresponds to the curves of your car's interior. The face (baffle) out of 18mm (or greater) MDF for strength and ease of mounting, with a trim ring out of machined and polished aluminium. Nice